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News Scan for Sep 09, 2022

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COVID boosters safe and well tolerated in pregnant and lactating womenCOVID vaccine boosters or third doses after an initial two-dose series are well tolerated in pregnant and lactating women, according to a large cohort study published yesterday in JAMA Network Open.A team at the University of Washington conducted a US-based online survey in January 2021 to examine patterns in adults who were pregnant, lactating, or planning pregnancy at the time of COVID vaccination.

They noted that, although earlier studies showed that the primary vaccine series was well tolerated and safe for pregnant and breastfeeding women, not much was known about their experiences with boosters.As of Apr 4, 2022, 17,014 participants reported they had received a COVID booster or third dose.

Of those 11.8% were pregnant, 60.4% were lactating, and 27.8% were neither. Most (82.8%) reported a local reaction, and 67.9% reported at least one systemic symptom after the additional vaccine dose.Very few reported obstetric or breastfeeding concerns after vaccination.

Compared to participants who weren't pregnant or lactating, pregnant women were more likely to report a local reaction (adjusted odds ratio [aOR], 1.2; 95% CI, 1.0 to 1.4; P = .01), but less likely to report systemic reactions (aOR, 0.7; 95% CI, 0.6 to 0.8; P < .001).The authors wrote that the frequencies of local and systemic reactions after the booster or third doses in all three groups was similar to those reported in vaccine trials for the general population, as well as for levels found in national safety surveillance systems for booster doses.

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