COVID vaccine doses may have weaker effect in immune-compromisedAfter two doses of an mRNA-based COVID-19 vaccine, nearly 90% of immunocompromised patients had an antibody response, but it was about as third as strong as those with healthy immune systems, according to data published in the Annals of Internal Medicine yesterday.Researchers recruited 133 adults who were receiving immunosuppressive therapies for chronic inflammatory diseases (CIDs) plus 53 adults with healthy immune systems from the San Francisco and St.
Louis areas. The most common CIDs were irritable bowel syndrome (31.6%) and rheumatoid arthritis (28.6%). All received two doses of the Pfizer/BioNTech or Moderna vaccine from Dec 1, 2020, to Mar 20, 2021, and they gave blood