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COVID-19 Scan for Mar 25, 2022

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Delta, Omicron COVID-19 variants caused more cases in pregnant womenThe highly transmissible Delta and Omicron SARS-CoV-2 variants caused triple and 10 times the rate of COVID-19 infections in pregnant women compared with other strains, with most cases among unvaccinated mothers and their newborns, finds a prospective study yesterday in JAMA.University of Texas researchers studied the outcomes of pregnant women diagnosed as having COVID-19 at a Dallas healthcare system.

The study spanned the pre-Delta period (May 17, 2020, to Jun 26, 2021), the Delta period (Jun 27 to Dec 11, 2021), and the Omicron era (Dec 12, 2021, to Jan 29, 2022).

COVID-19 vaccines became available in December 2020.A total of 2,641 maternal COVID-19 infections were diagnosed, with 1,298 pre-Delta (median per week, 17), 431 in the Delta period (14), and 912 during Omicron (138).Two infected mothers (0.15%) had completed the primary COVID-19 vaccine series before the emergence of Delta, while 49 (11.4%) and 256 (28.1%) did so during the Delta and Omicron periods, respectively.

Of the 2,641 infections, 112 (4.2%) were severe or critical, including 53 (4.1%) before Delta (0 vaccinated), 51 (11.8%) amid Delta (2 vaccinated), and 8 (0.9%) during Omicron.Relative to the pre-Delta period, the Delta and Omicron eras were tied to increased maternal infections (incidence rate ratios, 3.07 and 10.09, respectively).

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