Brazil's Sao Paulo-based Butantan Institute, a state-run medical research facility, on Wednesday began to manufacture ButanVac, the first Brazilian vaccine against the novel coronavirus disease (Covid-19), state governor Joao Doria announced."It will be the first vaccine manufactured entirely in Brazil, without the need to import raw materials," Doria said during a press conference at the institute, which is funded by the state government.Production began on the first of an expected 18 million doses by mid-July, though Brazil's Health Regulatory Agency (Anvisa) is yet to authorise the vaccine.The institute also makes and packages the CoronaVac vaccine developed by Chinese pharmaceutical firm Sinovac Life Sciences.