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Studies find no COVID benefit for preventive hydroxychloroquine or for convalescent plasma

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Two studies published yesterday in the New England Journal of Medicine found that two once-promising but largely discredited COVID-19 treatments—hydroxychloroquine and convalescent plasma—didn't prevent infection or lead to clinical improvement.'No compelling data'The first study, an open-label trial led by researchers at Hospital Germans Trias i Pujol in Barcelona, Spain, involved randomly assigning clusters of healthy adults with high-risk, close-contact exposure to a COVID-19 patient to either 800 milligrams (mg) of hydroxychloroquine followed by 6 days of 400-mg doses or usual care.Of 2,314 contacts of 672 COVID-19 patients identified from Mar 17 to Apr 28, 1,116 were assigned to receive hydroxychloroquine and 1,198 to usual care.

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