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Stem cells offer new glimpse at how the placenta emerges—and how the fetus-sustaining organ can fail

DNA Pregnancy patient
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www.sciencemag.org
sciencemag.org:

Kelly ServickThe placenta—a Frisbee-size hunk of tissue that chaperones a fetus in the uterus only to be tossed aside in the delivery room—has mysterious beginnings.

The organ emerges from cells that develop alongside the embryo, and that have been difficult to grow in the lab. Now, researchers have devised a way to derive and observe early precursors of placental cells in a dish.

They have found a method of “reprogramming” adult cells, reverting them to a primitive state, that can prompt them to become trophoblast stem cells (TSCs), which give rise to placental cells.The method promises a window on how defects in placental development may lead to infertility, miscarriage, and preeclampsia, a dangerous complication of pregnancy.

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COVID-19
United States
United States
Cases: 46 252 513
Deaths: 750 423
Recovered: 0
India
India
Cases: 34 321 025
Deaths: 459 652
Recovered: 0
Brazil
Brazil
Cases: 21 835 785
Deaths: 608 235
Recovered: 0
United Kingdom
United Kingdom
Cases: 9 215 683
Deaths: 141 607
Recovered: 0
Russia
Russia
Cases: 8 494 589
Deaths: 237 619
Recovered: 0
Detail statistic
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