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North Carolina man developed 'uncontrollable' Irish accent during prostate cancer treatment

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North Carolina man developed an "uncontrollable Irish accent" until his death after being treated for prostate cancer, according to research published in the British Medical Journal.The patient, who was only identified as a man in his 50s, was presumably afflicted with foreign accent syndrome (FAS) after receiving androgen deprivation therapy and being prescribed abiraterone acetate/prednisone.The report said the man lived in England during his 20s and had friends and distant family members from Ireland, but had never visited the country or spoken with the foreign accent."His accent was uncontrollable, present in all settings and gradually became persistent," the four researchers wrote in their report, adding that it first began 20 months into his treatment.WALKING DEAD SYNDROME AND OTHER RARE CONDITIONS THAT BAFFLE DOCTORS AND RESEARCHERSSeveral similar cases have been studied across the globe in recent years, but this was reportedly the first case of FAS described in a patient with prostate cancer and the third described in a patient with malignancy.The researchers believe his voice change was caused by a condition called paraneoplastic neurological disorder (PND), which happens when cancer patients' immune systems attack parts of their brain, muscles, nerves and spinal cord."Despite chemotherapy, his neuroendocrine prostate cancer progressed resulting in multifocal brain metastases and a likely paraneoplastic ascending paralysis leading to his death," they wrote.Even as his condition worsened, the accent remained until his death months later.

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