Review: COVID-19 vaccines not tied to lower fertility in men or womenA systematic review and meta-analysis today in Vaccine finds no link between COVID-19 vaccines and infertility in men or women.Researchers at a Rome hospital analyzed 29 studies from China, Israel, Italy, Russia, Turkey, Canada, and the United States until Jun 8, 2022.
Of the studies, 13.8% were deemed of poor quality, 58.6% were of moderate quality, and 27.6% were of good quality.Meta-analysis of studies of men before and after COVID-19 vaccination of any type showed similar sperm motility (44% vs 43%; 5 studies of 298 men), sperm concentration (50.6 million per milliliter [mln/mL] vs 55.4 mln/mL; 8 studies of 451 men), and sperm volume (2.6 vs 2.7 mL; 6 studies of 346 men).Among women, biochemical and clinical pregnancy rates (0.51 vs 0.48; 7 studies and 0.45 vs 0.47; 10 studies, respectively) were comparable among vaccinated and unvaccinated groups.
Biochemical pregnancy is defined as the presence of human chorionic gonadotropin (hCG), which can be detected as soon as 2 weeks after conception, while clinical signs of a fetus are detected only later.
Levels of estradiol, a hormone that can indicate ovarian function, were also similar in five studies.Fertility markers in men and women were unchanged before and after COVID-19 vaccination of any type (ie, Pfizer/BioNTech, Moderna, or Sputnik V).