Moderna COVID-19 vaccine is non-inferior in adolescentsModerna's COVID-19 vaccine was safe in adolescents 12 to 17 years old, with a similar immune response to that in young adults, according to results of an ongoing phase 2-3 trial published in the New England Journal of Medicine yesterday.The researchers assigned 3,732 participants two doses of either the Moderna vaccine or a placebo in a 2:1 ratio from Dec 9, 2020, to Feb 28, 2021.
The average age of the cohort was 14.3 years, 51% were male, and 84% were White. Participants were not excluded if they had experienced anaphylaxis or serious allergic reactions in the past, unless it was to a vaccine.Geometric mean titer ratio of pseudovirus neutralizing antibody titers in the intervention