Over the weekend, the global total topped 250 million cases as Delta (B1617.2) variant activity fuels fresh surges in Europe and keeps countries on other continents on an uncertain path heading into winter.The notable global high mark for infections comes about a week after the world passed 5 million deaths and as the pandemic's 2-year mark approaches.Grim total as pandemic resurgesAt a World Health Organization (WHO) media briefing on Nov 4, the group's COVID-19 technical lead, Maria Van Kerkhove, PhD, said virus activity is rising in places where it shouldn't be—in countries with ample vaccine and tools to fight the pandemic.She urged world leaders and health officials to channel their grief and anger over the pandemic's grim totals into