Regular physical activity may substantially reduce the risk of COVID-19–related hospitalization, intensive care unit (ICU) admission, and death, suggests an observational study of nearly 50,000 people published yesterday in the British Journal of Sports Medicine.Kaiser Permanente Southern California researchers led the retrospective study, which involved linking the self-reported physical activity levels of 48,440 adult patients who had at least three exercise vital sign measurements in the 2 years preceding the pandemic to their risk of severe coronavirus outcomes.Used at every outpatient visit at Kaiser Permanente since 2009, exercise vital sign measurements include average number of days a week of moderate to strenuous exercise and