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Covid ‘rebound’ symptoms: Why some test positive again, like US President Joe Biden?

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What is Paxlovid and how does it work? Paxlovid is a combination treatment that uses two different antivirals: nirmatrelvir and ritonavir.

Nirmatrelvir works to prevent the virus replicating. It does this by stopping a viral enzyme called a protease. SARS-CoV-2, like many viruses, rely on proteases to “activate" them.

Without the protease, the virus replication cycle cannot be completed and the virus can not become active. So rather than “killing" the virus, it stops new “active" virus particles from being made.

Ritonavir is a “boosting agent" which prevents the metabolism of nirmatrelvir, meaning it stays in your system for longer. Ritonavir has been used in low doses to boost the effectiveness of other protease antivirals in infections such as HIV.

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Benjamin Franklin-Parkway - 2022 Made in America Festival: Philadelphia announces road closures, parking restrictions ahead of event - fox29.com - state Pennsylvania - Philadelphia, state Pennsylvania - city Philadelphia, state Pennsylvania
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2022 Made in America Festival: Philadelphia announces road closures, parking restrictions ahead of event
PHILADELPHIA, PA - SEPTEMBER 02: Festivalgoes attend the 2018 Made In America Festival at Benjamin Franklin Parkway on September 2, 2018 in Philadelphia, Pennsylvania. (Photo by Zachary Mazur/FilmMagic) PHILADELPHIA - As the City of Philadelphia prepares to welcome thousands of visitors to the area for the 2022 Made in America Festival, officials have released information on road closures and other important details ahead of the Labor Day weekend event. The two-day event will take place on Saturday, September 3 and Sunday, September 4, with stages along the Benjamin Franklin Parkway. The festival is set to run both days from noon to midnight. RELATED: Made In America Festival 2022: Tyler, The Creator & Bad Bunny to headline annual two-day eventRoads in the area will begin closing to accommodate venue staff for the setup and clean-up of the event. The following road closures will be in effect the week of the event: Phase 1: Sunday, August 28 at 7 a.m. to Tuesday, September 6 at 11:59 p.m.Phase 2: Monday, August 29  at 7 a.m. to Tuesday, September 6 at 5 p.m.Phase 3: Tuesday, August 30  at 7 a.m. to Tuesday, September 6 at 11:59 p.m.Phase 4: Wednesday, August 31 at 10 a.m. to Tuesday, September 6 at 5 a.m.Phase 5: Thursday, September 1 at 7 p.m. to Tuesday, September 6 at 5 a.m. Phase 6: Friday, September 2 at 10 a.m. to Tuesday, September 6 at 5 a.m. Phase 7: Saturday, September 3 at 3 a.m. to Monday, September 5 at 5 a.m. Officials say all road closures will be lifted before morning rush hour on Tuesday, September 6. The following parking restrictions will be in effect: According to authorities, additional road closures and parking restrictions may be necessary near the event.
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