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COVID-19 survivors still at higher risk of neurologic disorders 2 years later

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Rates of "brain fog," dementia, psychotic disorders, and epilepsy or seizures remained elevated 2 years after COVID-19 infection, according to a study of nearly 1.3 million adults and children in the United States, Australia, Europe, and Asia.The study team, led by University of Oxford researchers, mined data on 14 neurologic and psychiatric disorders from the international TriNetX electronic health records network.

The database contains the deidentified hospital, primary care, and specialist records of about 89 million adult and pediatric patients from the United States and, to a lesser extent, Australia, the United Kingdom, Spain, Bulgaria, India, Malaysia, and Taiwan.The cohort of 1,284,437 patients tested positive for COVID-19 on or after Jan 20, 2020, and were matched in a 1:1 ratio with patients with non-COVID respiratory infections.

Follow-up ended on Apr 13, 2022. Of all patients, 185,748 were children, 856,588 were adults, 242,101 were older adults (aged 65 years or older), average age was 42.5 years, and 57.8% were female.Brain fog, dementia still elevated at 2 yearsThe risk of most disorders remained significantly elevated after 6 months (except for encephalitis, Guillain-Barre syndrome, nerve-related disorders, and parkinsonism [Parkinson's disease]), but their risk horizons and time to equal incidence differed considerably.The risk of common psychiatric disorders returned to baseline within 1 or 2 months (43 days for mood disorders, 58 days for anxiety disorders) and then equalized with that of controls by 1.1 years (anxiety) and 1.3 years (mood disorders).

But the risk of brain fog, dementia, psychotic disorders, and epilepsy or seizures stayed elevated at 2 years.Relative to adults, children's risk of mood

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