Prolonged SARS-CoV-2 shedding tied to in-hospital delirium, death by 6 monthsPersistent SARS-CoV-2 shedding in hospitalized COVID-19 patients is tied to a higher risk of in-hospital delirium and death by 6 months, according to a study published this week in GeroScience.A team led by Northwestern University researchers retrospectively evaluated viral shedding in 2,518 COVID-19 patients hospitalized in Illinois from Mar 5 to Aug 9, 2020.
A total of 959 patients were tested for SARS-CoV-2 using polymerase chain reaction (PCR) at least once 14 or more days after their initial positive test, 405 (42.2%) of whom were still shedding virus.
Average age of patients who underwent repeat testing was 59.4 years.Prolonged viral shedding was linked to male sex, higher body mass index, diabetes, chronic kidney disease, and corticosteroid treatment during initial COVID-19 hospitalization.
After adjustment for factors such as severity of respiratory dysfunction, shedding remained linked to in-hospital delirium (odds ratio [OR], 2.45) and death by 6 months (OR, 2.43).