Unvaccinated heart-failure patients at 3 times the risk for COVID-19 deathUnvaccinated heart-failure patients who contract COVID-19 are three times more likely to die of their infections than their vaccinated and boosted counterparts, concludes a study published yesterday in the Journal of Cardiac Failure.Researchers at the Icahn School of Medicine at Mount Sinai in New York studied the electronic health records of 7,094 heart-failure patients at a single health system with clinical visits from Jan 1, 2021, to Jan 24, 2022.
Average age was 73.3 years, 48% were women, and average follow-up was 276.5 days.Of all patients, 9.1% were partially vaccinated against COVID-19, 31.0% were fully vaccinated, 14.8% had received the one booster dose recommended at that time, and 45.1% were unvaccinated.Overall, 904 patients died.
Boosted patients had the lowest death rate, followed by the fully vaccinated (hazard ratios [HRs], 0.33; 95% confidence interval [CI], 0.23 to 0.48 and 0.36; 95% CI, 0.30 to 0.43, respectively), compared with their unvaccinated peers.
There were no differences between unvaccinated and partially vaccinated patients.Relative to unvaccinated or partially vaccinated patients, those who were fully vaccinated or boosted were also significantly less likely to be hospitalized (incidence rate ratio [IRR], 0.68; 95% CI, 0.65 to 0.71) or admitted to an intensive care unit (IRR, 0.63; 95% CI, 0.58 to 0.68).The researchers noted that while heart-failure patients are at high risk for poor COVID-19 outcomes, many hesitate to be vaccinated."I launched this study because our heart failure patients often express fear of getting the COVID-19 vaccine after hearing reports of vaccine-related myocarditis, which would cause another