Omicron likely less susceptible to antibodies from vaccinated peopleAustrian scientists writing in a letter in the New England Journal of Medicine yesterday demonstrate poor neutralization of the Omicron variant when using serum from vaccinated or recovered COVID-19 patients, potentially signaling a need for variant-specific vaccines.The highly transmissible Omicron (B.1.1.529) variant has caused COVID-19 cases and hospitalizations to skyrocket across the globe, even though it might cause less severe disease than previous variants.The researchers used blood from a variety of patients: 10 had been infected with the Alpha variant, 8 with Beta, and 7 with Delta.
Ten had received two doses of the Moderna vaccine, 10 the AstraZeneca-Oxford vaccine, and 20 the Pfizer-BioNTech vaccine; 20 participants had received both AstraZeneca and Pfizer vaccines.
In addition, 5 donors had been infected and subsequently received one or two doses of Pfizer, and 5 had been vaccinated with two doses of one of the three vaccines and had breakthrough infections.The team didn't analyze serum samples from people who had received a booster vaccine dose.Serum samples from vaccinated persons neutralized the Omicron variant to a much lesser extent than Alpha, Beta, or Delta.
The investigators found some cross-neutralization of Omicron in samples obtained from people who had received either the Pfizer vaccine or the AstraZeneca-Pfizer combo but not in samples from persons who had received AstraZeneca only.