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COVID-19 boosters offer good protection against early Omicron subvariants

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First and second COVID-19 vaccine booster doses conferred substantial protection against emergency department/urgent care (ED/UC) visits and hospitalizations caused by infections with the Omicron subvariants BA.1, BA.2, and BA.2.12.1, finds a study of adults in 10 US states published late last week in Morbidity and Mortality Weekly Report.The Centers for Disease Control and Prevention (CDC) COVID-19 Emergency Response Team led the study of 214,487 ED/UC visits and 58,782 hospitalizations with COVID-like illness from Dec 18, 2021, to Jun 10, 2022, to compare the vaccine effectiveness (VE) of two, three, and four mRNA COVID-19 vaccine doses (Pfizer/BioNTech or Moderna) or no vaccination against Omicron subvariants in adults with healthy immune systems.The BA.1 surge in the United States occurred from December 2021 to February 22, after which the BA.2/BA.2.12.1 surge began (BA.4 and BA.5 became dominant in June 2022).

The study didn't involve genetic sequencing of the causative subvariants but rather presumed the lineage from the dominant circulating strain at the time of diagnosis.Currently, a two-dose primary COVID-19 mRNA vaccination series and a third (booster) dose at least 5 months later is recommended for all adults with healthy immune responses.

On Mar 29, 2022, a fourth dose (second booster) was authorized for those 50 and older and those 12 and older with moderately or severely compromised immune systems at least 4 months after the third dose.Efficacy against ED/UC visitsOf the 214,487 ED/UC visits with a COVID-like illness diagnosis, 57.8% occurred during the BA.1-dominant era, when 32.9% of patients tested positive for COVID-19, and 42.2% of infections occurred during the BA.2/BA.2.12.1-dominant period, when

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Shawn Mendes cancels remaining Wonder tour dates over mental health: ‘I was not at all ready for how difficult touring would be’
Shawn Mendes announced that he has canceled all remaining dates of his Wonder tour, to prioritize his mental health.The Senorita singer previously postponed some of his scheduled performances earlier this month, and has now confirmed that his time on the road has been cut short.The 23-year-old shared the news on social media, penning a heartfelt statement to fans.‘As you guys know, I had to postpone the past few weeks of shows since I wasn’t totally prepared for the toll of being back on the road would take on me,’ he began.‘I started this tour excited to finally get back to playing live after a long break due to the pandemic, but the reality is I was not at all ready for how difficult touring would be after this time away.‘After speaking more with my team and working with an incredible group of health professionals, it has become more clear that I need to take the time I’ve never taken personally, to ground myself and come back stronger.’pic.twitter.com/gq7DanGNYW‘I unfortunately have to cancel the rest of the tour dates in North America, and the UK/Europe,’ he continued.‘We were hopeful that I might be able to pick up with the rest of the dates after some much needed time off, but at this time I have to put my health as my first priority.’Shawn explained that it ‘breaks his heart’ to scrap the remaining dates, and reassured fans that he would be getting back into the studio to record new music when he is able to.‘This doesn’t mean I won’t be making new music, and I can’t wait to see you on tour in the future,’ he added.‘I know you all have been waiting so long to see these shows, and it breaks my heart to tell you this but I promise I will be back as soon as I’ve taken the right time to heal.‘I love you all and thank
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