A study of 223 patients younger than 20 years hospitalized with the rare but serious COVID-19–related multisystem inflammatory syndrome in children (MIS-C) in New York City found that black children were disproportionately affected.The population-based cohort study, published as a research letter today in JAMA Network Open, involved analysis of the medical records and lab data of all pediatric MIS-C patients reported to the New York City Department of Health and Mental Hygiene from Mar 1 to Jun 30.MIS-C is believed to be an abnormal immune response to the novel coronavirus, similar to but distinct from Kawasaki disease.