Infection with the Alpha (B117) SARS-CoV-2 variant may pose a heightened risk of poor COVID-19 outcomes, according to two observational studies from England and Denmark published yesterday in The Lancet Infectious Diseases.65% higher odds of death in primary care groupIn the first study, a team led by University of Oxford researchers studied data on a primary care cohort and a critical care group, both of which were infected by the Alpha variant and tested positive for COVID-19 from November 2020 to January 2021.Of the 198,420-person primary care group, 59.4% were infected by Alpha, 0.4% were admitted to a critical care unit (CCU, similar to a US intensive care unit), and 0.4% died by 28 days.